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Urokinase thrombolysis using a multiple side hole multilumen infusion catheter
S L Kaufman1, L G Martin, B P Gilarsky
1Department of Radiology, Emory University School of Medicine, Atlanta, GA 30322.
Insights
A novel infusion catheter improved urokinase thrombolysis for peripheral artery blockages by reducing procedure time. This method achieved a 77% success rate, comparable to existing treatments, with minimal complications.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Thrombolytic Therapy
Background:
- Thromboembolic occlusions in peripheral arteries and grafts pose significant clinical challenges.
- Existing thrombolysis methods can be time-consuming and require frequent catheter repositioning.
Purpose of the Study:
- To evaluate the efficacy and safety of a multilumen, multiple side hole infusion catheter for urokinase thrombolysis.
- To assess the impact of this catheter on procedure efficiency and patient outcomes.
Main Methods:
- Utilized a multilumen, multiple side hole infusion catheter for urokinase thrombolysis in 13 patients.
- Performed adjunctive balloon angioplasty in 6 patients and atherectomy in 1 patient post-infusion.
- Monitored for complications, including hemorrhagic events.
Main Results:
- Achieved a 77% success rate for urokinase thrombolysis, consistent with literature findings.
- The specialized catheter eliminated the need for repositioning, reducing procedural time and facility burden.
- One hemorrhagic complication was reported, indicating a manageable safety profile.
Conclusions:
- The multilumen, multiple side hole infusion catheter is an effective tool for peripheral artery thrombolysis.
- This catheter design offers significant advantages in procedural efficiency and reduced staff workload.
- The success and safety profile are comparable to established thrombolytic techniques.
Abstract:
A multilumen, multiple side hole infusion catheter was used for urokinase thrombolysis in 13 patients with thromboembolic occlusions of peripheral arteries and grafts. Balloon angioplasty was performed following urokinase infusion in 6 patients and atherectomy in 1 patient. There was one hemorrhagic complication. The major advantage of the multiple sidehole infusion catheter was the elimination of the need to reposition the catheter during the infusion and the reduction of the time burden on the angiographic facility. The success rate for the thrombolysis (77%) was comparable to results recorded in the literature. The total duration of infusion was not reduced compared to other series.