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Related Experiment Videos

Urokinase thrombolysis using a multiple side hole multilumen infusion catheter.

S L Kaufman1, L G Martin, B P Gilarsky

  • 1Department of Radiology, Emory University School of Medicine, Atlanta, GA 30322.

Cardiovascular and Interventional Radiology
|November 11, 1991
PubMed
Summary

A novel infusion catheter improved urokinase thrombolysis for peripheral artery blockages by reducing procedure time. This method achieved a 77% success rate, comparable to existing treatments, with minimal complications.

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Area of Science:

  • Vascular Surgery
  • Interventional Radiology
  • Thrombolytic Therapy

Background:

  • Thromboembolic occlusions in peripheral arteries and grafts pose significant clinical challenges.
  • Existing thrombolysis methods can be time-consuming and require frequent catheter repositioning.

Purpose of the Study:

  • To evaluate the efficacy and safety of a multilumen, multiple side hole infusion catheter for urokinase thrombolysis.
  • To assess the impact of this catheter on procedure efficiency and patient outcomes.

Main Methods:

  • Utilized a multilumen, multiple side hole infusion catheter for urokinase thrombolysis in 13 patients.
  • Performed adjunctive balloon angioplasty in 6 patients and atherectomy in 1 patient post-infusion.
  • Monitored for complications, including hemorrhagic events.

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Main Results:

  • Achieved a 77% success rate for urokinase thrombolysis, consistent with literature findings.
  • The specialized catheter eliminated the need for repositioning, reducing procedural time and facility burden.
  • One hemorrhagic complication was reported, indicating a manageable safety profile.

Conclusions:

  • The multilumen, multiple side hole infusion catheter is an effective tool for peripheral artery thrombolysis.
  • This catheter design offers significant advantages in procedural efficiency and reduced staff workload.
  • The success and safety profile are comparable to established thrombolytic techniques.