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Related Experiment Video

Updated: Jul 14, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Published on: June 28, 2024

Folate status and mood: is there a relationship?

Emma Williams¹, Barbara Stewart-Knox, Chris McConville

¹Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, Northern Ireland.

Public Health Nutrition

|June 15, 2007

Summary

Higher red-blood-cell folate levels correlate with more stable negative mood in healthy males. This study suggests a link between long-term folate status and mood regulation.

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Area of Science:

Nutritional Neuroscience
Psychiatry
Human Physiology

Background:

Folate is essential for neurotransmitter synthesis.
Nutritional status may influence mood regulation.
Previous research has not extensively explored folate's impact on mood variability.

Purpose of the Study:

To investigate the association between folate status, homocysteine levels, and subjective mood in healthy adult males.
To determine if red-blood-cell (RBC) folate, serum folate, or plasma homocysteine concentrations correlate with mood states.

Main Methods:

Healthy males (n=58, aged 19-47) provided blood samples for folate and homocysteine analysis.
Subjective mood was assessed twice daily for one week using the Positive and Negative Affect Scale (PANAS).
Red-blood-cell (RBC) folate, serum folate, and plasma homocysteine concentrations were measured.

Main Results:

Elevated RBC folate concentrations were significantly associated with reduced variability in negative mood states (P=0.023).
No significant relationships were found between subjective mood and serum folate or plasma homocysteine levels.
The Positive and Negative Affect Scale (PANAS) was used to quantify mood states.

Conclusions:

This study is the first to report a link between long-term folate status and subjective mood stability in healthy males.
Further research is warranted to elucidate the complex relationship between nutritional status and mood.
Folate status may play a role in mood regulation, particularly in mitigating negative mood fluctuations.