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[Investigating the diagnostic value of MHC-I expression in polymyositis]
Shun-Chang Han1, Chuan-Qiang Pu, Sen-Yang Lang
1Department of Neurology, General Hospital of People's Liberation Army, Beijing 100853, China.
Objective:
To investigate the diagnostic value of MHC-I expression in PM.
Methods:
Analyzing the results of clinical and pathological findings and the immunohistochemical findings of MHC-I expression of 54 cases.
Results:
Among the 16 patients with PM, 63 percent patients showed inflammatory infiltration, 94 percent showed MHC-I expression; Among 19 patients with progressive muscular dystrophy, 9 percent patients showed inflammatory infiltration, 11 percent showed MHC-I expression. The other 19 patients showed no inflammatory infiltration and MHC-I expression.
Conclusion:
MHC-I expression as a diagnostic index of PM was appropriate, which had ideal sensitivity, specificity and negative likelihood ratio.
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