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Related Concept Videos

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its effects by...
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Stimulants

Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
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Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
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Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Adrenergic Agonists: Indirect-Acting Agents

Indirect-acting adrenergic agonists potentiate the effects of endogenous catecholamines through different mechanisms without directly binding to adrenoceptors.
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral bioavailability, and...

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Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
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Published on: February 18, 2016

[Consequences of cocaine use among prostitutes].

Carmen Meneses Falcón1

  • 1Facultad de Ciencias Humanas y Sociales, Universidad Comillas de Madrid, España. cmeneses@chs.upcomillas.es

Gaceta Sanitaria
|June 15, 2007
PubMed
Summary

Cocaine use among sex workers in Spain was often instrumental, reducing inhibitions and increasing earnings. However, this drug use was linked to higher risks of unprotected sex and violence.

Area of Science:

  • Social Sciences
  • Public Health
  • Criminology

Background:

  • Prostitution is a complex social issue with significant public health implications.
  • Substance use, particularly cocaine, is prevalent among individuals involved in sex work.
  • Understanding the dynamics of drug use in this population is crucial for targeted interventions.

Purpose of the Study:

  • To investigate the circumstances surrounding cocaine use within the context of prostitution.
  • To identify the consequences of cocaine consumption for individuals engaged in sex work.
  • To explore harm reduction strategies employed by sex workers who use drugs.

Main Methods:

  • A qualitative research design was employed, utilizing fieldwork across six Spanish cities.
  • Semi-structured interviews were conducted with 60 participants aged 18–50 involved in street, flat, or brothel-based prostitution.

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  • Data collection focused on experiences with alcohol and cocaine use in relation to sex work.
  • Main Results:

    • Alcohol and cocaine were the primary substances used, often instrumentally to reduce inhibitions and increase work capacity.
    • Cocaine use facilitated longer working hours and engagement with clients for non-sexual company, potentially increasing income.
    • Consequences included increased risk of unprotected sex and client-related violence; harm reduction strategies were observed.

    Conclusions:

    • A significant association exists between drug use and the provision of sexual services.
    • Cocaine use in prostitution poses considerable health risks, notably through increased likelihood of unprotected sexual encounters.
    • Harm reduction practices are actively implemented by sex workers to mitigate risks associated with substance use.