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Pregnancy-associated plasma protein-A and asthma
Abdurrahman Coskun1, Oner Balbay, Sadik Duran
1Department of Clinical Biochemistry, Duzce University, School of Medicine, Duzce, Turkey. coskun_a2002@yahoo.com
Advances in Therapy
|June 15, 2007
Summary
Pregnancy-associated plasma protein-A (PAPP-A) is elevated in asthma patients and correlates with disease severity. This inflammatory marker may play a role in airway smooth muscle hyperplasia in asthma.
Area of Science:
- Biochemistry
- Immunology
- Pulmonology
Background:
- Pregnancy-associated plasma protein-A (PAPP-A) is recognized as a metalloproteinase with proatherosclerotic properties.
- PAPP-A is also emerging as a novel inflammatory marker.
- Its role in respiratory diseases like asthma is not well understood.
Purpose of the Study:
- To investigate the significance of PAPP-A in patients diagnosed with asthma.
- To determine if PAPP-A levels differ between asthma patients and healthy controls.
- To explore the correlation between PAPP-A concentration and asthma severity.
Main Methods:
- Serum samples were collected from 35 asthma patients and 20 control subjects.
- Serum PAPP-A levels were quantified using enzyme-linked immunosorbent assay (ELISA).
- Statistical analysis was performed to compare groups and assess correlations.
Main Results:
- Asthma patients exhibited significantly higher serum PAPP-A levels (8.1+/-5.0 mU/L) compared to the control group (4.9+/-2.1 mU/L) (P<.01).
- A significant positive correlation was observed between serum PAPP-A concentration and asthma severity (r=.581; P<.01).
Conclusions:
- PAPP-A is elevated in patients with asthma.
- Serum PAPP-A levels are significantly correlated with asthma severity.
- PAPP-A may contribute to airway smooth muscle hyperplasia in asthma, potentially via its role as an insulin-like growth factor-binding protein-4 protease.
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