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Updated: Jul 14, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Radiotherapy for Erdheim-Chester disease.

Katsunori Matsui1, Yasushi Nagata, Masahiro Hiraoka

  • 1Department of Radiology, Maizuru Municipal Hospital, Kyoto, Japan. k-matsui@hospital.toyooka.hyogo.jp

International Journal of Clinical Oncology
|June 15, 2007
PubMed
Summary

Radiation therapy effectively managed bone pain in a patient with Erdheim-Chester disease (ECD), an uncommon histiocytosis. This case highlights radiotherapy as a potential treatment option for localized ECD symptoms.

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Area of Science:

  • Oncology
  • Radiology
  • Pathology

Background:

  • Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis.
  • Treatment for ECD remains controversial, with limited established therapeutic guidelines.
  • Bone involvement is a common and debilitating manifestation of ECD.

Observation:

  • A 42-year-old female presented with bilateral leg pain and fever.
  • Initial steroid therapy provided only temporary relief for her symptoms.
  • Progressive bone pain in the right femur necessitated further intervention.

Findings:

  • The patient was diagnosed with Erdheim-Chester disease via bone biopsy.
  • A trial course of radiation therapy (18 Gy in 10 fractions) was administered to the right distal femur.

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  • Radiotherapy resulted in a gradual response, achieving local pain control.

    • Implications:

    • This case suggests radiotherapy may be a viable treatment for symptomatic bone lesions in Erdheim-Chester disease.
    • Further research is warranted to explore the role of radiation therapy in ECD management.
    • Radiotherapy offers a potential non-systemic treatment option for localized ECD manifestations.