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Updated: Jul 14, 2026

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

[Proteomics: biomarker research in psychiatry].

R Hünnerkopf¹, J Grassl, J Thome

¹Department of Psychiatry, The School of Medicine, University of Wales Swansea, UK.

Fortschritte Der Neurologie-Psychiatrie

|June 15, 2007

Summary

Genomics in brain disorders has limitations. Proteomics offers a deeper understanding of molecular mechanisms by analyzing proteins, aiding in biomarker discovery and targeted drug development for psychiatric conditions.

Related Concept Videos

Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Area of Science:

Neuroscience
Psychiatry
Molecular Biology

Context:

Genomics research in psychiatry and neuroscience has yielded insights but clinical applications for brain disorders remain limited.
Understanding complex molecular processes in neuropsychiatric disorders requires examining proteins beyond DNA and mRNA due to alternative splicing and posttranslational modifications.

Purpose:

To highlight the utility of proteomics in unraveling signal transduction pathways and protein interaction networks in brain disorders.
To explore the potential of proteomics in identifying diagnostic and prognostic biomarkers for psychiatric diseases.
To discuss the role of proteomics in developing targeted pharmaceutical agents with reduced side effects.

Summary:

Proteomics utilizes high-throughput mass spectrometry to identify protein expression levels, posttranslational modifications, and protein-protein interactions.

Related Experiment Videos

Last Updated: Jul 14, 2026

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status

Published on: October 20, 2016

Proteomic analysis of postmortem brain tissue, cerebrospinal fluid (CSF), or serum can reveal quantitative and qualitative protein patterns.

Comparing protein profiles in healthy versus diseased states is crucial for biomarker discovery and understanding disease etiology and pathomechanisms.

Impact:

Proteomics provides a more comprehensive view of molecular mechanisms in brain disorders compared to genomics alone.
This approach can lead to the development of specific diagnostic and prognostic biomarkers for conditions like Alzheimer's disease, drug addiction, schizophrenia, and depression.
Proteomic studies can inform the design of more effective and safer medications for psychiatric conditions.