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Updated: Jul 14, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Effective monoallylation of anilines catalyzed by supported KF
Vittorio Pace1, Fernando Martínez, María Fernández
1Organic and Pharmaceutical Chemistry Department, Pharmacy Faculty, Complutense University, 28040-Madrid, Spain.
Abstract:
A mild and straightforward monoallylation procedure for different anilines is described using the efficient, inexpensive, noncorrosive, and environmentally friendly reagent KF-Celite. By using only a 1/1.2 stoichiometric ratio of electrophilic reagent to aniline, in very short reaction times, the monoallylated products are obtained in high isolated yields via this procedure, which works very effectively regardless of the electronic nature of the substituent on the ring, although electron withdrawing groups make the reactions go even faster.
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