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Related Concept Videos

Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
Redox Reactions01:24

Redox Reactions

Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...

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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
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Published on: December 23, 2016

Tunable disassembly of micelles using a redox trigger.

Suhrit Ghosh1, Katharine Irvin, S Thayumanavan

  • 1Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.

Langmuir : the ACS Journal of Surfaces and Colloids
|June 15, 2007
PubMed
Summary

Researchers developed stimuli-responsive micelles using disulfide linkers for controlled disassembly. Mixing with co-surfactants precisely tunes the release rate of encapsulated molecules.

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science

Background:

  • Stimuli-responsive materials offer dynamic control over molecular assembly and release.
  • Micelles formed by surfactants are versatile nanostructures for encapsulation and delivery.

Purpose of the Study:

  • To design and demonstrate a simple stimuli-responsive micellar system.
  • To control micellar disassembly kinetics and encapsulated molecule release rates.

Main Methods:

  • Synthesis of surfactant molecules with redox-sensitive disulfide linkers.
  • Formation of micelles and mixed micelles with co-surfactants.
  • Kinetic studies of micellar disassembly and dye release.

Main Results:

  • Successfully designed stimuli-responsive micelles based on disulfide-linked surfactants.
  • Demonstrated tunable disassembly kinetics by varying co-surfactant ratios.
  • Achieved controlled release of encapsulated dye molecules.

Conclusions:

  • Redox-sensitive disulfide linkers provide a simple route to stimuli-responsive micellar systems.
  • Co-surfactant addition offers a practical method for tuning disassembly and release rates.
  • This approach enables controlled delivery applications.