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Related Experiment Videos

Evidence that neurotensin mediates postprandial intestinal hyperemia in the python, Python regius.

Nini Skovgaard1, J Michael Conlon, Tobias Wang

  • 1Zoophysiology, Department of Biological Sciences, Aarhus University, 8000 Aarhus C, Denmark. nini.jensen@biology.au.dk

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
|June 15, 2007
PubMed
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Neurotensin (NT) is a key mediator of post-meal intestinal hyperemia in pythons, significantly increasing mesenteric blood flow. While NT influences cardiac output at high doses, its role in cardiac responses during python digestion appears minor.

Area of Science:

  • Comparative Physiology
  • Gastrointestinal Physiology
  • Endocrinology

Background:

  • Digestion in pythons causes significant increases in heart rate and cardiac output.
  • Postprandial intestinal hyperemia is observed, but its mediators remain unidentified.
  • The role of neurotensin (NT) in these physiological responses is unknown.

Purpose of the Study:

  • To investigate the role of neurotensin (NT) as a mediator of postprandial intestinal hyperemia in pythons.
  • To determine the effects of NT on cardiovascular parameters in pythons.
  • To elucidate the mechanisms underlying NT-induced cardiovascular changes.

Main Methods:

  • Administration of python neurotensin ([His(3), Val(4), Ala(7)]NT) via bolus intra-arterial injections in anesthetized and unanesthetized pythons.

Related Experiment Videos

  • Dose-dependent assessment of systemic and pulmonary hemodynamics, including pressure, flow, and conductance.
  • Pharmacological blockade experiments using propranolol (beta-adrenergic) and histamine H(2)-receptor antagonists.

    • Main Results:

    • Python NT induced dose-dependent vasodilation, decreased systemic pressure, and increased systemic blood flow in anesthetized pythons.
    • Significant increases in heart rate and cardiac output were observed only at high NT doses (>30 pmol/kg).
    • In unanesthetized pythons, low-dose NT significantly increased mesenteric blood flow and conductance without altering systemic hemodynamics or heart rate.

    Conclusions:

    • Neurotensin (NT) is identified as a significant hormonal mediator of postprandial intestinal hyperemia in pythons.
    • NT's vasodilatory effects on the mesenteric vascular bed are independent of beta-adrenergic and histamine H(2)-receptor pathways.
    • NT's contribution to cardiac responses during python digestion appears to be minor compared to its role in intestinal hyperemia.