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A mouse model to evaluate the interface between skin and a percutaneous device.

S N Isenhath1, Y Fukano1, M L Usui1

  • 1Department of Medicine/Dermatology, University of Washington, Seattle, Washington.

Journal of Biomedical Materials Research. Part A
|June 15, 2007
PubMed
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This study developed an animal model to test skin integration with medical devices, aiming to prevent infections. Results showed skin integrated into porous biomaterial rods, suggesting a potential barrier against bacterial invasion.

Area of Science:

  • Biomaterials Science
  • Infectious Disease Research
  • Medical Device Development

Background:

  • Percutaneous medical devices can lead to infections due to the space between the skin and the device, allowing bacterial invasion and biofilm formation.
  • Preventing infection at the implant site is crucial for effective disease management and treatment using medical devices.

Purpose of the Study:

  • To develop and validate an animal model for evaluating the interaction between skin and biomaterials.
  • To assess the potential of integrating skin into a device to create a barrier against bacterial invasion.

Main Methods:

  • Porous poly(2-hydroxyethyl methacrylate) [poly(HEMA)] rods were implanted subcutaneously in mice for 7 days.
  • Rods were surface-modified with carbonyldiimidazole (CDI) or CDI plus laminin 5, with unmodified rods as controls.

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  • Implant sites were sealed using 2-octyl cyanoacrylate, and stabilization was tested with dressings.

    • Main Results:

    • Histological analysis confirmed epidermal and dermal integration into all implanted poly(HEMA) rods, irrespective of surface modification.
    • All implants remained intact throughout the 7-day study period.
    • The developed animal model successfully demonstrated the interaction between skin and the biomaterial implant.

    Conclusions:

    • The study successfully established an in vivo animal model for examining the implant/skin interface.
    • Skin integration into porous poly(HEMA) rods suggests a viable strategy for creating a barrier against bacterial invasion at percutaneous device sites.
    • This model will be valuable for future research focused on enhancing skin cell attachment to percutaneous devices to prevent infections.