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Pin1 in neuronal apoptosis.

Esther B E Becker1, Azad Bonni

  • 1Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Cell Cycle (Georgetown, Tex.)
|June 15, 2007
PubMed
Summary
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The prolyl isomerase Pin1 activates mitochondrial cell death in neurons. This process involves JNK-mediated phosphorylation of BIM(EL), linking it to neuronal apoptosis and neurologic disorders.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • The function of prolyl isomerase Pin1 in dividing cells is established.
  • Pin1's role in postmitotic neurons remains largely unknown.

Purpose of the Study:

  • To elucidate the function of Pin1 in postmitotic neurons.
  • To identify novel mechanisms of neuronal apoptosis.

Main Methods:

  • Investigated Pin1's role in neuronal cell death pathways.
  • Analyzed JNK-mediated phosphorylation of BIM(EL) and its link to Pin1.

Main Results:

  • Identified a novel Pin1-mediated activation of mitochondrial cell death in neurons.
  • Discovered that JNK-phosphorylated BIM(EL) at serine 65 triggers neuronal apoptosis.

Related Experiment Videos

  • Pin1 acts as a molecular switch coupling BIM(EL) phosphorylation to apoptosis in neurons.

    • Conclusions:

    • Pin1 is crucial for activating the mitochondrial cell death pathway specifically in neurons.
    • Findings provide insights into nervous system development and neurologic disease pathogenesis.