Related Experiment Video
Updated: Jul 14, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[New highlight of acute interstitial pneumonia]
E Fernández Fabrellas1, M L Domingo Montañana, E Martínez Moragón
1Sevicio de Neumología, Hospital Universitario Dr. Peset, Valencia, España. esferfa@saludalia.com
Revista Clinica Espanola
|June 15, 2007
Summary
Acute interstitial pneumonia (AIP) is a rare lung disease. Early intervention and HR-CT findings may improve prognosis, despite high mortality rates and risk of fibrosis.
Area of Science:
- Pulmonology
- Pathology
- Radiology
Context:
- Acute interstitial pneumonia (AIP) is a rare idiopathic interstitial pneumonia with a historically high mortality rate.
- Diagnostic criteria have been based on limited case series, potentially biasing outcome and prognosis assessments.
- Despite its long recognition, AIP remains a challenging diagnosis with significant patient impact.
Purpose:
- To review the current understanding of Acute Interstitial Pneumonia (AIP).
- To highlight the diagnostic challenges and prognostic factors associated with AIP.
- To emphasize the potential benefits of early intervention and HR-CT findings in managing AIP.
Summary:
- Acute interstitial pneumonia (AIP) is a distinct entity within idiopathic interstitial pneumonias, characterized by significant morbidity and mortality.
- Established diagnostic features rely on limited patient data, impacting accurate prognosis.
- Recent findings suggest improved outcomes with early intervention and specific High-Resolution Computed Tomography (HR-CT) findings.
Impact:
- Improved understanding of AIP prognosis through HR-CT and early intervention.
- Potential for earlier diagnosis and treatment initiation in AIP patients.
- Reduced mortality and complication rates associated with Acute Interstitial Pneumonia.
Related Concept Videos
01:29Pneumonia I: Introduction
Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
01:30Pneumonia I: Introduction
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
01:14Atypical Pneumonia
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
01:29Pneumonia II: Pathophysiology
The pathophysiology of pneumonia involves the following steps:
01:21Acute Respiratory Failure-II
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
01:30Acute Respiratory Failure-III
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without causing...