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Related Experiment Videos

Presenilin-mediated signal transduction.

Richard F Cowburn1, Bogdan O Popescu, Maria Ankarcrona

  • 1Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, KI-Alzheimer's Disease Research Center, Novum, plan 5, S-141 57 Huddinge, Sweden. richard.cowburn@astrazeneca.com

Physiology & Behavior
|June 15, 2007
PubMed
Summary
This summary is machine-generated.

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Presenilin proteins influence Alzheimer's disease by altering calcium signaling pathways. Mutations disrupt calcium release and entry, impacting cell function and disease progression.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Presenilin proteins are implicated in early-onset familial Alzheimer's disease.
  • Mutated presenilins affect cell signal transduction, particularly intracellular calcium signaling.
  • Previous research focused on endoplasmic reticulum calcium release and capacitative calcium entry.

Purpose of the Study:

  • To review how presenilins modulate intracellular calcium signaling.
  • To explore the role of deregulated calcium homeostasis in Alzheimer's disease pathogenesis.
  • To highlight a novel function of presenilins in regulating phospholipase C activity.

Main Methods:

  • Literature review of presenilin function in calcium signaling.
  • Analysis of mechanisms involving inositol(1,4,5)trisphosphate (InsP3) mediated calcium release.

Related Experiment Videos

  • Investigation of presenilin regulation of acetylcholine muscarinic receptor-stimulated phospholipase C.

    • Main Results:

    • Presenilin mutations can potentiate InsP3-mediated calcium release from the endoplasmic reticulum.
    • Mutations may also attenuate capacitative calcium entry.
    • Presenilins regulate phospholipase C activity upstream of InsP3-mediated calcium release.

    Conclusions:

    • Presenilins play a critical role in modulating intracellular calcium homeostasis.
    • Dysregulation of calcium signaling by presenilins is a potential contributor to Alzheimer's disease.
    • Further research into presenilin-mediated calcium signaling is crucial for understanding Alzheimer's disease.