Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Hand eczema is common and multifactorial.

Pieter-Jan Coenraads¹

¹Dermatology Department, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands. p.j.coenraads@med.umcg.nl

The Journal of Investigative Dermatology

|June 15, 2007

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cochrane review "Interventions for hand eczema" is published.

Contact dermatitis·2019

Same author

Interventions for hand eczema.

The Cochrane database of systematic reviews·2019

Same author

The significance of batch and patch test method in establishing contact allergy to fragrance mix I-EDEN Fragrance Study Group.

Contact dermatitis·2019

Same author

Immediate hypersensitivity to p-phenylenediamine.

Contact dermatitis·2018

Same author

Allergy Alert Test for p-Phenylenediamine-Allergic Hair Dye Users.

Dermatitis : contact, atopic, occupational, drug·2018

Same author

The attitude of patients with p-phenylenediamine or 2,5-toluenediamine contact allergy to hair dyeing.

Contact dermatitis·2017

Same journal

Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations.

The Journal of investigative dermatology·2026

Same journal

Charting a new melanoma risk factor: Satellite Naevus Prevalence in High-Risk and Population-Based Cohorts.

The Journal of investigative dermatology·2026

Same journal

Human keratinocytes and fibroblasts coordinate early cutaneous innate defenses against Candida auris.

The Journal of investigative dermatology·2026

Same journal

Merkel cells attenuate autoantigen-specific T cell driven skin inflammation in mice associated with reduced neutrophil recruitment.

The Journal of investigative dermatology·2026

Same journal

The response of human melanocytic nevi to simulated solar radiation assessed by single-nucleus RNA sequencing of frozen tissue.

The Journal of investigative dermatology·2026

Same journal

Impact of Online vs In-Person Management of Atopic Dermatitis on Quality of Life and Access to Care: A Randomized Controlled Trial.

The Journal of investigative dermatology·2026

See all related articles

Hand eczema is multifactorial, with atopic dermatitis a key factor, but allergies are often overestimated. Twin studies help differentiate genetic predispositions from environmental triggers for better prevention strategies.

Area of Science:

Dermatology
Epidemiology
Genetics

Background:

Hand eczema is recognized as a complex condition with multiple contributing factors.
While atopic dermatitis is considered a significant risk factor, the influence of allergies may be overstated in clinical understanding.

Discussion:

Twin studies offer a valuable methodology to disentangle the relative contributions of endogenous (genetic) and exogenous (environmental) factors in hand eczema etiology.
Understanding these distinct pathways is crucial for developing targeted prevention and intervention strategies.

Key Insights:

The etiology of hand eczema is multifactorial, involving both genetic predispositions and environmental exposures.
Current clinical assumptions may overestimate the role of allergies while underappreciating other endogenous factors.

Related Experiment Videos

Outlook:

Further research utilizing twin studies can elucidate the precise interplay between genetic susceptibility and environmental triggers.
This knowledge will pave the way for more effective, personalized prevention and management of hand eczema.