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Updated: Jul 14, 2026
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Acute disseminated encephalomyelitis in classic dengue.
Carlos A A Brito1, Silvana Sobreira, Marli Tenório Cordeiro
1Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife, PE.
Revista Da Sociedade Brasileira De Medicina Tropical
|June 15, 2007
Summary
Neurological complications are rare in dengue fever. This case study details acute disseminated encephalomyelitis in dengue, a rare central nervous system condition, highlighting significant brain damage.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- Neurological manifestations are infrequently observed in dengue virus infections.
- The exact mechanisms behind dengue-induced central nervous system (CNS) involvement remain debated.
- Classic dengue cases rarely present with severe neurological sequelae.
Observation:
- A rare instance of acute disseminated encephalomyelitis (ADEM) was diagnosed in a patient with classic dengue fever.
- Dengue virus serotype 3 was successfully isolated from the cerebrospinal fluid (liquor) of the affected patient.
- The patient exhibited substantial structural abnormalities in the brain, as evidenced by magnetic resonance imaging (MRI).
Findings:
- The study documents a unique case linking dengue infection to ADEM.
- Isolation of dengue serotype 3 from cerebrospinal fluid provides etiological evidence.
- MRI findings confirmed significant structural brain damage associated with this neurological complication.
Implications:
- This case expands the spectrum of known neurological complications associated with dengue virus.
- Understanding the pathogenesis of dengue-related ADEM is crucial for diagnosis and management.
- Further research is warranted to elucidate the mechanisms of CNS damage in dengue infections.
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