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Related Concept Videos

Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...

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Related Experiment Video

Updated: Jul 14, 2026

Enhanced Photoluminescence of Curcuma longa Extracts via Chitosan-Mediated Energy Transfer for Textile Authentication Applications
09:50

Enhanced Photoluminescence of Curcuma longa Extracts via Chitosan-Mediated Energy Transfer for Textile Authentication Applications

Published on: December 22, 2023

Molecular targets of curcumin.

Jen-Kun Lin1

  • 1Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan. jklin@ha.mc.ntu.edu.tw

Advances in Experimental Medicine and Biology
|June 16, 2007
PubMed
Summary

Curcumin, a natural compound, exhibits anti-inflammatory and anti-cancer properties by inhibiting key signaling pathways and protein targets. It induces apoptosis by disrupting the ubiquitin-proteasome pathway, suggesting its potential as a cancer chemopreventive agent.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Cancer Research

Background:

  • Curcumin demonstrates significant anti-inflammatory effects.
  • It inhibits enzymes involved in reactive oxygen species production and key signaling kinases.
  • Curcumin is recognized for its potential as a cancer chemopreventive agent.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying curcumin's anti-cancer and anti-inflammatory activities.
  • To identify upstream and downstream molecular targets of curcumin.
  • To explore curcumin's role in signal transduction pathways and apoptosis.

Main Methods:

  • Inhibition of reactive oxygen-generating enzymes (e.g., lipoxygenase, cyclooxygenase, iNOS).
  • Inhibition of protein kinases (e.g., PKC, EGFR tyrosine kinase, IkappaB kinase).

Related Experiment Videos

Last Updated: Jul 14, 2026

Enhanced Photoluminescence of Curcuma longa Extracts via Chitosan-Mediated Energy Transfer for Textile Authentication Applications
09:50

Enhanced Photoluminescence of Curcuma longa Extracts via Chitosan-Mediated Energy Transfer for Textile Authentication Applications

Published on: December 22, 2023

  • Analysis of downstream effects on oncogene expression and signal transduction pathways (e.g., NF-KB, MAPKs).
  • Investigation of curcumin's impact on the ubiquitin-proteasome pathway and induction of apoptosis.

    • Main Results:

    • Curcumin effectively inhibits multiple pro-inflammatory enzymes and kinases.
    • It suppresses the activation of NF-KB and the expression of oncogenes.
    • Curcumin targets upstream molecules like PKC and EGFR tyrosine kinase, and downstream targets including c-jun, c-fos, and iNOS.
    • Curcumin induces apoptosis through the impairment of the ubiquitin-proteasome pathway.

    Conclusions:

    • Curcumin suppresses tumor promotion by blocking critical signal transduction pathways.
    • Its ability to modulate protein kinase C and induce apoptosis via the ubiquitin-proteasome pathway highlights its therapeutic potential.
    • Curcumin's multifaceted molecular actions position it as a promising agent in cancer chemoprevention and therapy.