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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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Related Experiment Video

Updated: Jul 14, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Curcumin and autoimmune disease.

John J Bright1

  • 1Neuroscience Research Laboratory, Methodist Research Institute, Clarian Health, Indianapolis, IN 46202, USA. jbright1@clarian.org

Advances in Experimental Medicine and Biology
|June 16, 2007
PubMed
Summary

Curcumin, a compound from turmeric, shows promise in managing autoimmune diseases by regulating inflammatory pathways. Further research is needed to determine safe and effective therapeutic doses for human use.

Area of Science:

  • Immunology
  • Pharmacology
  • Natural Products

Background:

  • Autoimmune diseases affect over 5% of the global population, leading to conditions like multiple sclerosis and rheumatoid arthritis.
  • While the exact causes remain unknown, herbal supplements are increasingly used by patients due to their perceived safety and affordability.
  • Curcumin, derived from Curcuma longa, is a traditional remedy with emerging evidence for its anti-inflammatory properties.

Purpose of the Study:

  • To review the potential of curcumin as a therapeutic agent for autoimmune diseases.
  • To explore the mechanisms by which curcumin modulates immune responses and inflammatory pathways.
  • To highlight the need for precise dosing and safety guidelines for therapeutic curcumin use.

Main Methods:

  • Literature review of studies investigating curcumin's effects on autoimmune disease models (human and animal).

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Labeling and Imaging of Amyloid Plaques in Brain Tissue Using the Natural Polyphenol Curcumin

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An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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Labeling and Imaging of Amyloid Plaques in Brain Tissue Using the Natural Polyphenol Curcumin

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  • Analysis of curcumin's impact on key inflammatory cytokines (e.g., IL-1beta, TNF-alpha) and signaling pathways (e.g., JAK-STAT, NF-kappaB).
  • Evaluation of existing data on curcumin's efficacy and safety in managing autoimmune conditions.

    • Main Results:

    • Curcumin has demonstrated ameliorative effects in models of multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
    • It functions by regulating critical inflammatory cytokines and inhibiting signaling pathways involved in immune cell activation.
    • Studies indicate curcumin's potential to mitigate key inflammatory processes underlying autoimmune diseases.

    Conclusions:

    • Curcumin exhibits significant potential in managing autoimmune diseases through its immunomodulatory and anti-inflammatory actions.
    • Understanding the precise effective dose, safe regimen, and mechanism of action is crucial for its clinical application.
    • Further research is warranted to establish standardized protocols for using purified curcumin therapeutically in human autoimmune diseases.