Related Experiment Video
Updated: Jul 14, 2026
A Modified Inflammatory Pain Model to Study the Analgesic Effect in Mice
Published on: November 15, 2024
[Aike mixture has good anti-inflammatory and analgesic effects on mice]
Min-jian Zhang1, Ke-dan Chu, Xin-ling Cheng
1Department of Andrology, People's Hospital Affiliated to Fujian College of Traditional Chinese Medicine, Fuzhou, Fujian 350004, China. zmj83@tom.com
Objective:
To study the anti-inflammatory and analgesic actions of Aike Mixture (AKM).
Methods:
A total of 100 male mice were randomly assigned into 5 groups: a normal control group, a drug control group (a hydrocortisone subgroup and an atropine subgroup), a high-dose AKM group, a mid-dose AKM group and a low-dose AKM group. Xylene was spread on the left ear of the experimental mice to induce inflammation, and 1% acetic acid solution injected into the abdominal cavity to produce pain so as to cause the body bend. Different doses of AKM were given and their actions observed.
Results:
AKM had obvious anti-inflammatory effect on the xylene-induced ear tumefaction and inhibited the pain-caused body bend in the AKM groups, with significant difference from the normal control (P < 0.01).
Conclusion:
AKM has good anti-inflammatory and analgesic effects, which is of clinical significance in the treatment of chronic prostatitis.
