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Experimental Manipulation of Body Size to Estimate Morphological Scaling Relationships in Drosophila
Published on: October 1, 2011
[Adaptive norm and stabilizing selection for anthropometric characters at birth]
Insights
This study reveals that birth weight significantly impacts infant survival, with higher risks observed outside the adaptive norm. Neonatal mortality is strongly linked to birth weight, indicating intense natural selection in newborns.
Area of Science:
- Pediatric Medicine
- Developmental Biology
- Biostatistics
Context:
- Analysis of medical records from thousands of healthy and affected infants.
- Focus on differential mortality and morbidity in newborns and infants.
- Investigation of anthropometric traits at birth, including birth weight and body length.
Purpose:
- To define the adaptive norm for anthropometric traits at birth.
- To estimate relative risk of mortality and morbidity as a function of birth weight and body length.
- To quantify the intensity of stabilizing selection in the neonatal and infant periods.
Summary:
- Identified patterns of differential mortality and morbidity in infants based on birth weight and length.
- Defined the adaptive norm as anthropometric ranges with lower-than-average mortality/morbidity rates.
- Calculated stabilizing selection intensity for birth weight, finding it significantly higher in neonates than infants (1-12 months).
Impact:
- Over 50% of neonatal mortality can be attributed to stabilizing selection related to birth weight.
- Highlights the critical role of birth weight in early life survival.
- Provides quantitative insights into evolutionary selection pressures on human infants.
Abstract:
Analysis carried out on medical documentation containing data on several thousand healthy and affected babies has revealed patterns of differential mortality and differential morbidity for newborns and infants which allow to estimate relative risk as a function of birth weight and body length. Adaptive norm for anthropometric traits at birth was defined as the weight or length interval in which mortality/morbidity rates were lower than the overall population level. The intensity of stabilizing selection associated with birth weight calculated from these data is several times higher in the neonatal period than for the age interval 1-12 months. Neonatal mortality in more than 50% cases can be attributed to the effects of stabilizing selection associated with birth weight.
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