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Related Experiment Videos

Hepsin and prostate cancer.

Qingyu Wu1, Gordon Parry

  • 1Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA. wuq@ccf.org

Frontiers in Bioscience : a Journal and Virtual Library
|June 16, 2007
PubMed
Summary
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Hepsin, a serine protease, is increasingly expressed in prostate cancer, promoting tumor progression and metastasis. Targeting hepsin may offer a new strategy for prostate cancer treatment.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Oncology

Background:

  • Hepsin is a membrane-bound serine protease found in human liver, kidney, prostate, and thyroid tissues.
  • Its precise physiological role is currently unknown.
  • Hepsin is known to activate several factors in vitro, including blood clotting factors (VII, XII, IX), pro-urokinase (pro-uPA), and pro-hepatocyte growth factor (pro-HGF).

Purpose of the Study:

  • To review the molecular biology and biochemistry of hepsin.
  • To highlight recent findings on hepsin's role in prostate cancer development and progression.

Main Methods:

  • Literature review of molecular biology and biochemistry studies on hepsin.
  • Analysis of recent data linking hepsin expression to prostate cancer.

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Main Results:

  • Hepsin is significantly upregulated in prostate cancer, with expression levels correlating to disease progression.
  • Overexpression of hepsin in a mouse model accelerated prostate cancer progression and metastasis.
  • Inhibition of hepsin using antibodies reduced the invasiveness of human prostate cancer cells in culture.

Conclusions:

  • Hepsin plays a critical role in promoting prostate cancer progression and metastasis.
  • The upregulation of hepsin in prostate cancer suggests it as a potential therapeutic target.