Related Experiment Video
Updated: Jul 14, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
Published on: January 20, 2019
Architecture and dynamics of the transcription factor network that regulates B-to-plasma cell differentiation
Kazuhiko Igarashi1, Kyoko Ochiai, Akihiko Muto
1Department of Biochemistry, Tohoku University Graduate School of Medicine, Seiryo-machi 2-1, Sendai 980-8575, Japan. igarak@mail.tains.tohoku.ac.jp
Abstract:
Upon antigen stimulation, B lymphoid cells undergo terminal differentiation into antibody-secreting plasma cells. This process accompanies drastic changes in cell functions such as a loss of B-cell identity, induction of secretory apparatus, and an extremely increased transcription of antibody genes. These changes are the result of re-wiring of a transcription factor network in B and plasma cells. While the transcription repressor Blimp-1 induces plasma cell differentiation, another repressor Bach2 has emerged as a negative regulator of Blimp-1 in B cells. These two transcription factors, together with other several factors, appear to constitute a main transcriptional regulatory network for the terminal differentiation process of plasma cells from B cells.
More Related Videos
11:06Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
Published on: September 20, 2017
13:55Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
Published on: February 3, 2013
Related Concept Videos
General Transcription Factors
B Cell Activation and Differentiation
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Transcription Factors
Transcription Factors
Master Transcription Regulators
TGF - β Signaling Pathway