Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute Bronchiolitis, Pediatric Acute Respiratory Distress Syndrome, and Sepsis: Leading Journal Reads and What This Means.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026
Same author

The editor replies.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026
Same author

Pediatric Critical Illness Investigation and Understanding Survival Biology.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026
Same author

Writing for Pediatric Critical Care Medicine: Using a Research Letter as an Option for Publication.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026
Same author

Connecting Clinical Practice Guidelines with Bundles, Implementation, and Quality Improvement Studies.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026
Same author

Writing for Pediatric Critical Care Medicine: What is Our Focus for Surveys and Questionnaire Studies.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2026

Related Experiment Video

Updated: Jul 14, 2026

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
07:01

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

Published on: February 7, 2025

Traumatic brain injury induced hypothalamic-pituitary dysfunction: a paediatric perspective.

Carlo L Acerini1, Robert C Tasker

  • 1Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Level 8/Box 116, Cambridge CB2 2QQ, UK. cla22@cam.ac.uk

Pituitary
|June 16, 2007
PubMed
Summary

Traumatic brain injury (TBI) can cause long-term pituitary hormone problems in children. Early detection and multidisciplinary care are crucial for managing these endocrine complications and supporting development.

More Related Videos

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats
07:36

A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats

Published on: December 8, 2014

Related Experiment Videos

Last Updated: Jul 14, 2026

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
07:01

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

Published on: February 7, 2025

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats
07:36

A Novel Model of Mild Traumatic Brain Injury for Juvenile Rats

Published on: December 8, 2014

Area of Science:

  • Pediatric Endocrinology
  • Neuroendocrinology
  • Traumatic Brain Injury Research

Background:

  • Anterior pituitary hormone dysfunction is a significant cause of long-term morbidity in traumatic brain injury (TBI) survivors.
  • While recognized in adults, pituitary dysfunction post-TBI in children and adolescents is less understood.
  • Hypothalamic-pituitary structures are vulnerable to head injury, potentially leading to delayed endocrine complications.

Purpose of the Study:

  • To review existing pediatric data on hypopituitarism following TBI.
  • To highlight the common endocrine abnormalities and potential complications in pediatric TBI survivors.
  • To emphasize the need for prospective studies on the incidence, natural history, and treatment of pediatric hypopituitarism post-TBI.

Main Methods:

  • Review of published pediatric literature on endocrine outcomes after TBI.
  • Analysis of reported cases of pituitary dysfunction in children and adolescents following mild to severe TBI.
  • Identification of common hormone deficiencies and pubertal disturbances.

Main Results:

  • Hypopituitarism is a recognized complication of TBI in children, occurring after both mild and severe injuries.
  • Growth hormone deficiency and gonadotropin deficiency are the most frequent abnormalities.
  • Central precocious puberty has also been observed in pediatric TBI survivors.

Conclusions:

  • Early detection of pituitary hormone abnormalities is vital due to the critical role of these hormones in childhood development.
  • Prospective studies are needed to establish the incidence, prevalence, and natural history of hypopituitarism in pediatric TBI survivors.
  • A multidisciplinary approach involving endocrine assessment is recommended for the long-term management and rehabilitation of children and adolescents with moderate to severe TBI.