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Related Experiment Videos

A motion maintaining antibiotic delivery system.

Adolph V Lombardi1, Jonathan M Karnes, Keith R Berend

  • 1Joint Implant Surgeons, Inc, New Albany, Ohio 43054, USA.

The Journal of Arthroplasty
|August 25, 2007
PubMed
Summary
This summary is machine-generated.

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Articulating antibiotic cement spacers are crucial for treating deep joint replacement infections. This method improves patient outcomes and facilitates future surgeries by delivering antibiotics locally.

Area of Science:

  • Orthopedic Surgery
  • Biomaterials Science
  • Infectious Disease Management

Background:

  • Deep infection in total joint arthroplasty (TJA) necessitates complex treatment protocols.
  • Two-stage radical debridement with implant removal, antibiotic therapy, and delayed reimplantation is the standard of care.
  • Articulating spacers offer advantages over static spacers in TJA infection management.

Purpose of the Study:

  • To describe the fabrication and use of articulating antibiotic-laden cement spacers for TJA deep infections.
  • To highlight the benefits of articulating spacers in improving functional outcomes and patient satisfaction.
  • To detail the antibiotic loading and molding process for effective local drug delivery.

Main Methods:

  • Utilizing a mold system for creating disposable femoral and tibial articulating cement spacers.

Related Experiment Videos

  • Vacuum mixing low-viscosity cement with specific dosages of tobramycin/gentamicin and vancomycin.
  • Injection-filling molds, curing, and trimming spacers for loose cementation into the joint space.

    • Main Results:

    • The described method allows for the creation of custom-fit articulating spacers.
    • These spacers serve as a vehicle for sustained local antibiotic delivery.
    • The process facilitates reimplantation and aims to preserve bone stock.

    Conclusions:

    • Articulating antibiotic-laden cement spacers are a valuable component in the management of deep TJA infections.
    • This technique enhances functional recovery and patient satisfaction while mitigating complications.
    • The mold system provides a reproducible method for spacer fabrication.