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Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Asymmetric Lipid Bilayer01:35

Asymmetric Lipid Bilayer

Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
What are Lipids?01:38

What are Lipids?

Overview

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Related Experiment Video

Updated: Jul 14, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Oxidized phospholipids: from molecular properties to disease.

Gilbert O Fruhwirth1, Alexandra Loidl, Albin Hermetter

  • 1Institute of Biochemistry, Graz University of Technology, Petersgasse 12/2, A-8010 Graz, Austria.

Biochimica Et Biophysica Acta
|June 16, 2007
PubMed
Summary

Oxidized lipids, generated during oxidative stress, exhibit diverse biological activities. Understanding their molecular features is key to their role in diseases like atherosclerosis.

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Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies
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Last Updated: Jul 14, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies
07:31

Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies

Published on: September 1, 2023

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pathophysiology

Background:

  • Oxidative stress generates oxidized lipids from phospholipids.
  • These lipids possess varied structures, properties, and biological activities.

Purpose of the Study:

  • To review the molecular features of oxidized phospholipids.
  • To elucidate their biological actions and pathophysiological roles.

Main Methods:

  • Review of chemical structures of oxidized phospholipids.
  • Discussion of their physical and biochemical properties.
  • Analysis of biological activities and receptor interactions.

Main Results:

  • Oxidized phospholipids' activities depend on molecular structure and receptor recognition.
  • They exert both specific and unspecific effects on biological systems.
  • Their role as mediators in atherosclerosis is highlighted.

Conclusions:

  • Molecular features are crucial for understanding oxidized phospholipid actions.
  • Oxidized phospholipids are significant in disease pathogenesis, particularly atherosclerosis.