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A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
Advances in vasospasm treatment and prevention
Ricardo J Komotar1, Brad E Zacharia, Ricky Valhora
1Department of Neurosurgery, Columbia University, New York, NY, USA.
Journal of the Neurological Sciences
|June 16, 2007
Summary
Subarachnoid hemorrhage (SAH) can lead to cerebral vasospasm (CV), a condition requiring further research. Current treatments include medical therapy and endovascular procedures, with future therapies on the horizon.
Area of Science:
- Neurosurgery
- Neurology
- Vascular Medicine
Background:
- Subarachnoid hemorrhage (SAH) outcomes are influenced by initial severity, medical management, surgical factors, and complications.
- Cerebral vasospasm (CV) following SAH presents challenges due to inconsistent treatment responses.
- Understanding SAH-induced cerebrovascular dysfunction necessitates further investigation into CV mechanisms.
Purpose of the Study:
- To review current therapies for cerebral vasospasm (CV) after aneurysmal subarachnoid hemorrhage (aSAH).
- To discuss potential future research directions for managing SAH-induced cerebrovascular dysfunction.
- To highlight the need for improved understanding and treatment of CV.
Main Methods:
- Literature review of existing studies on CV management after aSAH.
- Analysis of current therapeutic strategies, including medical and endovascular interventions.
- Discussion of emerging research and potential novel therapies.
Main Results:
- Current management involves maximal medical therapy (e.g., triple H regimen, calcium antagonists) and endovascular options (balloon angioplasty, vasodilators) for refractory cases.
- Cerebral vasospasm remains a significant complication with variable treatment efficacy.
- Elucidation of CV pathophysiology is crucial for developing more effective treatments.
Conclusions:
- Optimizing SAH patient outcomes requires addressing CV effectively.
- Continued research into the mechanisms of CV is essential.
- Advancements in understanding pathophysiology will drive the development of novel investigational therapies for CV.
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