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Updated: Jul 14, 2026

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
08:12

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage

Published on: July 28, 2018

Advances in vasospasm treatment and prevention

Ricardo J Komotar1, Brad E Zacharia, Ricky Valhora

  • 1Department of Neurosurgery, Columbia University, New York, NY, USA.

Journal of the Neurological Sciences
|June 16, 2007
PubMed

Insights

Subarachnoid hemorrhage (SAH) can lead to cerebral vasospasm (CV), a condition requiring further research. Current treatments include medical therapy and endovascular procedures, with future therapies on the horizon.

Area of Science:

  • Neurosurgery
  • Neurology
  • Vascular Medicine

Background:

  • Subarachnoid hemorrhage (SAH) outcomes are influenced by initial severity, medical management, surgical factors, and complications.
  • Cerebral vasospasm (CV) following SAH presents challenges due to inconsistent treatment responses.
  • Understanding SAH-induced cerebrovascular dysfunction necessitates further investigation into CV mechanisms.

Purpose of the Study:

  • To review current therapies for cerebral vasospasm (CV) after aneurysmal subarachnoid hemorrhage (aSAH).
  • To discuss potential future research directions for managing SAH-induced cerebrovascular dysfunction.
  • To highlight the need for improved understanding and treatment of CV.

Main Methods:

  • Literature review of existing studies on CV management after aSAH.
  • Analysis of current therapeutic strategies, including medical and endovascular interventions.
  • Discussion of emerging research and potential novel therapies.

Main Results:

  • Current management involves maximal medical therapy (e.g., triple H regimen, calcium antagonists) and endovascular options (balloon angioplasty, vasodilators) for refractory cases.
  • Cerebral vasospasm remains a significant complication with variable treatment efficacy.
  • Elucidation of CV pathophysiology is crucial for developing more effective treatments.

Conclusions:

  • Optimizing SAH patient outcomes requires addressing CV effectively.
  • Continued research into the mechanisms of CV is essential.
  • Advancements in understanding pathophysiology will drive the development of novel investigational therapies for CV.

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