Jove
Visualize
Contact Us

Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Germline Pathogenic Variants in MUTYH Are Associated With Inferior Survival After Hematopoietic Cell Transplantation in Patients With Hematologic Malignancies or Disorders.

American journal of hematology·2025
Same author

REMOVED: Conditioning Regimen Considerations for Allogeneic Hematopoietic Cell Transplantation in Recipients with Germline Pathogenic Variants in Base-Excision Repair Pathway Genes.

Transplantation and cellular therapy·2025
Same author

Psychosocial correlates of failure to complete hematopoietic stem cell transplants in a diverse population.

Bone marrow transplantation·2025
Same author

Donor Type Does Not Impact Late Graft Failure Following Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis.

Transplantation and cellular therapy·2025
Same author

Minnelide suppresses GVHD and enhances survival while maintaining GVT responses.

JCI insight·2024
Same author

Cryopreservation and storage patterns of hematopoietic progenitor stem cells for multiple myeloma.

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis·2023
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 14, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Models and mechanisms in malignant melanoma.

Cara L Benjamin1, Vladislava O Melnikova, Honnavara N Ananthaswamy

  • 1Department of Immunology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

Molecular Carcinogenesis
|June 16, 2007
PubMed
Summary

Human melanoma, the fastest-growing US malignancy, has a debated etiology, particularly concerning ultraviolet (UV) radiation. This review explores UV exposure, melanoma models, and genetic factors like BRAF mutations in melanoma development.

More Related Videos

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

A Melanoma Patient-Derived Xenograft Model
07:07

A Melanoma Patient-Derived Xenograft Model

Published on: May 20, 2019

Related Experiment Videos

Last Updated: Jul 14, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

A Melanoma Patient-Derived Xenograft Model
07:07

A Melanoma Patient-Derived Xenograft Model

Published on: May 20, 2019

Area of Science:

  • Oncology
  • Dermatology
  • Genetics

Background:

  • Human melanoma is the most rapidly increasing cancer in the United States.
  • The exact causes of melanoma and the role of ultraviolet (UV) radiation are subjects of ongoing scientific debate.
  • Understanding melanoma's etiology is crucial for developing effective prevention and treatment strategies.

Purpose of the Study:

  • To review the relationship between UV radiation exposure and melanoma development.
  • To discuss various melanoma models and genetic alterations involved in melanocyte oncogenic transformation.
  • To analyze the significance of specific genetic mutations, including BRAF and RAS, in melanoma predisposition.

Main Methods:

  • Review of existing scientific literature on UV radiation and melanoma.
  • Analysis of data from diverse melanoma models.
  • Examination of genetic alterations associated with melanocyte transformation.
  • Discussion of historical and current research on key genetic mutations (p16INK4a, MC1R, RAS, BRAF).

Main Results:

  • UV radiation is a significant factor in melanoma initiation and progression.
  • Specific genetic alterations, such as p16(INK4a) deletion, MC1R variants, and mutations in RAS and BRAF, are linked to melanoma development.
  • The BRAF 'hot spot' mutation shows potential significance comparable to activating RAS mutations in oncogenesis.

Conclusions:

  • UV exposure is a critical environmental factor in human melanoma.
  • Genetic predisposition, influenced by mutations in genes like BRAF and RAS, plays a substantial role in melanoma development.
  • Further research into these genetic factors can inform targeted prevention and therapeutic approaches for melanoma.