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Related Experiment Video

Updated: Jul 14, 2026

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
09:22

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

Regional right ventricular dysfunction in chronic pulmonary hypertension.

Virginija Dambrauskaite1, Marion Delcroix, Piet Claus

  • 1Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|June 16, 2007
PubMed
Summary

Ultrasonic strain rate imaging reveals regional right ventricular (RV) dysfunction in pulmonary hypertension (PH). Apical RV free wall function is particularly impaired, correlating with disease severity.

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Last Updated: Jul 14, 2026

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Area of Science:

  • Cardiology
  • Medical Imaging
  • Pulmonary Hypertension Research

Background:

  • Right ventricular (RV) failure is a primary cause of mortality in pulmonary hypertension (PH).
  • Accurate assessment of RV function is crucial for managing PH patients.
  • Interest is growing in advanced imaging techniques for evaluating RV performance.

Purpose of the Study:

  • To assess regional RV function in PH patients using ultrasonic strain rate imaging.
  • To identify specific patterns of RV dysfunction in the free wall.
  • To correlate regional RV function with hemodynamic parameters and exercise capacity.

Main Methods:

  • 27 PH patients and 27 controls underwent ultrasonic strain rate imaging.
  • Regional longitudinal deformation of the RV free wall was measured in basal and apical segments.
  • A subset of 16 patients had invasive hemodynamic measurements for correlation.

Main Results:

  • PH patients showed significantly reduced deformation parameters (strain rate and strain) compared to controls.
  • Apical RV segments exhibited greater impairment than basal segments (P < .002 for strain rate, P < .0001 for strain).
  • Reduced apical deformation correlated strongly with RV afterload, pulmonary arterial pressure, and pulmonary vascular resistance.

Conclusions:

  • Strain rate imaging is a valuable tool for quantifying regional RV dysfunction in PH.
  • A characteristic pattern of abnormal RV free wall function, particularly in the apex, was identified.
  • This technique aids in understanding the relationship between regional RV function and PH severity.