Related Experiment Video
Updated: Jul 14, 2026

Working with Human Tissues for Translational Cancer Research
Published on: November 26, 2015
Do cancer patients fully understand clinical trial participation? A pilot study to assess informed consent and
Ricardo J Wray1, Jo Ellen Stryker, Eric Winer
1Department of Community Health, Saint Louis University School of Public Health, St. Louis, MO 63104, USA. wray@slu.edu
Background:
Accepted practices of informed consent often result in suboptimal patient understanding of research studies.
Methods:
This pilot study aimed to assess trial-specific tailored materials, compared to a widely used generic booklet about clinical trials, randomly assigned to 118 candidates for cancer clinical trials. Study outcomes were: satisfaction with decision-making; satisfaction with materials; and subjective understanding of the clinical trial.
Results:
There were no major differences between groups. Participants rated tailored materials higher as a useful reference.
Conclusions:
Trial-specific materials hold utility for reference during clinical trials. Studies of informed consent are feasible, although important factors limit research.
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