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Prevalence of hepatitis E virus antibodies in patients with chronic hepatitis B and chronic hepatitis C

A Bayram1, F Eksi, M Mehli

  • 1Department of Microbiology and Clinical Microbiology, Gaziantep University Faculty of Medicine, Gaziantep, Turkey. aysenbayram@hotmail.com

Intervirology
|June 16, 2007
PubMed

Insights

Hepatitis E virus (HEV) infection is significantly more common in patients with chronic hepatitis C virus (HCV) than in those with chronic hepatitis B virus (HBV) or healthy individuals. This suggests a shared transmission route and highlights the need for HEV prevention in HCV patients.

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) are significant global health concerns.
  • Hepatitis E virus (HEV) is an emerging pathogen with various genotypes and transmission routes.

Purpose of the Study:

  • To determine the prevalence of HEV infection in patients with chronic HBV and chronic HCV.
  • To compare HEV prevalence between chronic hepatitis patients and a control group.

Main Methods:

  • Serum samples were collected from 190 chronic HBV patients, 174 chronic HCV patients, and 178 healthy controls.
  • Anti-HEV IgG antibodies were detected using serological assays.

Main Results:

  • HEV IgG positivity was 13.7% in chronic HBV patients and 54% in chronic HCV patients.
  • The control group showed 15.7% anti-HEV IgG positivity.
  • HEV infection prevalence was significantly higher in chronic HCV patients compared to chronic HBV patients and controls.

Conclusions:

  • HEV and HCV may share common transmission routes, particularly in the studied region.
  • Chronic HCV patients are at higher risk for HEV superinfection.
  • Preventive measures against HEV are recommended for chronic HCV patients due to potential for severe disease patterns.
Abstract

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