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[Effects of norepinephrine on brain oxygen saturation]
Kiyotaka Sato1, Hideyuki Kamii, Hiroaki Shimizu
1Department of Neuroanesthesia, Kohnan Hospital, Sendai.
Masui. the Japanese Journal of Anesthesiology
|June 19, 2007
Summary
Norepinephrine (NE) administration during carotid endarterectomy (CEA) decreased brain oxygen saturation (rSO2) in patients. This suggests NE may worsen cerebral oxygen balance, necessitating further research on its effects during CEA.
Area of Science:
- Neuroscience
- Cardiovascular Physiology
- Surgical Anesthesia
Context:
- Carotid endarterectomy (CEA) requires maintaining blood pressure and cerebral perfusion.
- Vasopressors are frequently needed during CEA, particularly during carotid clamping.
- The impact of vasopressors on cerebral circulation during CEA is not fully understood.
Purpose:
- To investigate the effect of norepinephrine (NE) on cerebral circulation during CEA.
- To monitor regional oxygen saturation (rSO2) in the frontal lobes during NE infusion in CEA patients.
Summary:
- Norepinephrine administration increased mean arterial pressure (MAP) and decreased heart rate (HR).
- Bilateral frontal rSO2 significantly decreased following NE infusion (ipsilateral P<0.01, contralateral P<0.05).
- These findings indicate NE reduces cerebral oxygenation during CEA.
Impact:
- Norepinephrine may negatively impact the balance between cerebral oxygen supply and demand in CEA patients.
- The study highlights potential risks associated with using NE to maintain MAP during CEA.
- Further research is needed to fully elucidate the cerebral circulatory effects of systemic norepinephrine in this context.
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