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NADH oxidase and fumarate reductase of Ancylostoma ceylanicum
N Goyal1, S Gupta, J C Katiyar
1Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
International Journal for Parasitology
|October 1, 1991
Abstract:
Ancylostoma ceylanicum, the hookworm parasite of cat, dog and man, was found to contain NADH and/or NADPH oxidase as well as fumarate reductase activities. Both the enzyme systems were predominantly located in the membranes of mitochondrial-rich preparations. The membranes also exhibited the presence of a reduced pyridine nucleotide transhydrogenase activity which transferred hydrogen from NADPH to NAD. Amongst respiratory inhibitors, rotenone (Site I inhibitor) markedly depressed both NADH oxidase and fumarate reductase while others, namely antimycin-A, KCN and azide, had a lesser effect.