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Related Experiment Video

Updated: Jul 14, 2026

Salinity-dependent Toxicity Assay of Silver Nanocolloids Using Medaka Eggs
06:29

Salinity-dependent Toxicity Assay of Silver Nanocolloids Using Medaka Eggs

Published on: March 18, 2016

Salinomycin toxicosis in horses.

Monica Aleman1, K Gary Magdesian, Tracy S Peterson

  • 1Department of Medicine, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.

Journal of the American Veterinary Medical Association
|June 19, 2007
PubMed
Summary

Ionophore toxicosis from feed supplements caused sudden weakness and ataxia in horses. This condition, linked to salinomycin, can lead to neurological damage, muscle wasting, and impaired performance in surviving animals.

Related Experiment Videos

Last Updated: Jul 14, 2026

Salinity-dependent Toxicity Assay of Silver Nanocolloids Using Medaka Eggs
06:29

Salinity-dependent Toxicity Assay of Silver Nanocolloids Using Medaka Eggs

Published on: March 18, 2016

Area of Science:

  • Veterinary Toxicology
  • Equine Neurology
  • Animal Nutrition

Background:

  • Sudden onset of neurological signs including ataxia and recumbency in horses can be challenging to diagnose.
  • Commercial feed supplements are widely used in equine diets, necessitating an understanding of their potential toxicities.

Observation:

  • A 4-month-old foal and five other horses exhibited progressive ataxia, weakness, and recumbency shortly after introduction of a new feed supplement batch.
  • Clinical findings included neurological deficits, mild leukocytosis, hyperglycemia, and elevated creatine kinase; however, routine diagnostics for heavy metals, selenium, and vitamin E were unremarkable.
  • Feed analysis revealed high concentrations of the ionophore antimicrobial salinomycin.

Findings:

  • Histopathology of the euthanized foal revealed severe neuronal vacuolation in dorsal root ganglia, consistent with ionophore toxicosis.
  • Surviving horses developed muscle atrophy, persistent weakness, and ataxia, indicating long-term neurological sequelae.
  • Salinomycin, an ionophore, was identified as the toxic agent in the feed supplement.

Implications:

  • Ionophore toxicosis should be a key differential diagnosis for acute neurological presentations and sudden death in horses.
  • This condition can manifest as poor performance, muscle wasting, and cardiac arrhythmias, impacting athletic horses.
  • Survivors of ionophore toxicosis may experience chronic neurological deficits and reduced athletic capability, highlighting the importance of early detection and prevention.