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Updated: Jul 14, 2026

Investigating the Neural Mechanisms of Aware and Unaware Fear Memory with fMRI
Published on: October 6, 2011
Influence of comorbid depression on fear in posttraumatic stress disorder: an fMRI study
Andrew H Kemp1, Kim Felmingham, Pritha Das
1Brain Dynamics Centre, Westmead Hospital and Western Clinical, School University of Sydney, Sydney, NSW, Australia. kempa@psych.usyd.edu.au
Abstract:
Posttraumatic Stress Disorder (PTSD) is thought to involve a dysregulation of medial prefrontal-amygdala activity in response to fear. PTSD studies, however, have been confounded by comorbid depression, which shows similar dysregulation. Amygdala and medial prefrontal activity was reduced in PTSD-depression compared to PTSD-alone samples, highlighting the need to account for comorbidity.
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