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Updated: Jul 14, 2026
09:15
Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
Published on: May 7, 2019
Simple "closed-circuit" group-specific immunoadsorption system for ABO-incompatible kidney transplants
Bela Balint1, Mirjana Pavlovic, Miodrag Jevtic
1Institute for Medical Research, University of Belgrade, Serbia. belab@imi.bg.ac.yu
Summary
A new pre-conditioning protocol for ABO-incompatible kidney transplants, using anti-CD20 antibody and immunoadsorption, effectively reduces harmful antibodies and shows promising clinical results safely and cost-effectively.
Area of Science:
- Nephrology
- Immunology
- Transplantation
Background:
- ABO-incompatible kidney transplants face challenges with antibody-mediated graft rejection.
- Advancements in pre-conditioning protocols and monitoring enable transplantation for previously ineligible patients.
Purpose of the Study:
- To evaluate a novel pre-conditioning protocol for ABO-incompatible kidney transplants.
- To assess the efficacy and safety of a protocol combining anti-CD20 antibody, therapeutic plasma exchange (TPE), and immunoadsorption without splenectomy.
Main Methods:
- Developed a closed-circuit immunoadsorption technique integrated with TPE.
- Administered anti-CD20 antibody and standard immunosuppressive treatment.
- Monitored ABO antibody levels and clinical outcomes.
Main Results:
- Achieved high-quality ABO antibody depletion (p<0.001).
- Observed beneficial clinical findings with no significant alteration in plasma constituents.
- Demonstrated a safe protocol without apheresis side effects or clinical consequences.
Conclusions:
- The designed pre-conditioning protocol is effective and safe for ABO-incompatible kidney transplants.
- This protocol offers a cost-effective approach to kidney transplantation.
- Larger randomized trials are needed for definitive conclusions.
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