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Updated: Jul 14, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
[Significance of permanent atrial fibrillation in idiopathic dilated cardiomyopathy]
B Brembilla-Perrot1, O Marçon, F Chometon
1Service de cardiologie, CHU de Brabois, rue du Morvan, 54500 Vandoeuvre-lès-Nancy, France. b.brembilla-perrot@chu-nancy.fr
Insights
Older age is linked to permanent atrial fibrillation (AF) in idiopathic dilated cardiomyopathy (IDCM). Permanent AF does not worsen ventricular tachycardia risk or overall prognosis in IDCM patients.
Area of Science:
- Cardiology
- Electrophysiology
Context:
- Idiopathic dilated cardiomyopathy (IDCM) is a significant cause of heart failure.
- The role of atrial fibrillation (AF) in IDCM prognosis is not fully understood.
- Understanding AF's impact is crucial for managing IDCM patients.
Purpose:
- To investigate the clinical significance of permanent atrial fibrillation (AF) in patients with idiopathic dilated cardiomyopathy (IDCM).
- To determine if permanent AF affects the risk of ventricular tachycardia or overall prognosis in IDCM.
Summary:
- A study of 323 IDCM patients with left ventricular ejection fraction <40% compared those with permanent AF (n=65) to those in sinus rhythm.
- Patients with permanent AF were older.
- No significant differences were observed in syncope, sustained ventricular tachycardia, left ventricular ejection fraction, or VT induction between groups.
- Follow-up revealed no statistical differences in sudden death, heart failure deaths, or heart transplantation rates.
Impact:
- Older age is the sole clinical factor associated with permanent AF in IDCM.
- Permanent AF does not appear to increase the risk of sustained ventricular tachycardia induction.
- The presence of permanent AF does not negatively impact the general prognosis of idiopathic dilated cardiomyopathy.
Unlabelled:
The significance of atrial fibrillation (AF) in idiopathic dilated cardiomyopathy (IDCM) remains discussed. The purpose of the study was to evaluate the clinical significance of permanent atrial fibrillation in patients with IDCM.
Methods:
Systematic noninvasive and invasive studies including Holter monitoring, measurement of left ventricular ejection fraction (LVEF), electrophysiological study and coronary angiography were performed in 323 patients with IDCM; all patients had a left ventricular ejection fraction (LVEF)<40%. The studies were indicated for spontaneous ventricular tachycardia (VT) in 69 patients, syncope in 103 patients and nonsustained VT on Holter monitoring in 151 asymptomatic patients. Sixty-five patients were in permanent AF (group I). Remaining patients were in sinus rhythm at the time of evaluation (group II). Programmed ventricular stimulation using up to 3 extrastimuli in control state and if necessary after isoproterenol was systematic. Patients were followed 3+/-2 years.
Results:
Mean age was significantly older in group I (61+/-8 years) than in group II (52+/-12) (P<0.01). Syncope (31 vs 36%), spontaneous sustained VT (18 vs 23%); mean LVEF (28+/-9% vs 29+/-9%), VT induction (25 vs 35%) were similar in both groups. During the follow-up, there were no statistical differences between groups I and II concerning each event: sudden death occurred in 13 patients, 1.5% of group I patients and 5% of group II patients (NS); a death related to heart failure occurred 22 patients, 5% of group I patients and 7% of group II patients (NS); heart transplantation was performed in 13 patients, 8% of group I patients and 3% of group II patients (NS).
Conclusions:
An older age is the only significant clinical factor associated with the presence of a permanent atrial fibrillation in idiopathic dilated cardiomyopathy. The presence of permanent AF does not increase the induction of a sustained ventricular tachycardia and does not affect the general prognosis of IDCM.
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