Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Medullary thyroid carcinoma].

P Niccoli-Sire1, B Conte-Devolx

  • 1Service d'endocrinologie, diabète et maladies métaboliques, Assistance publique-Hôpitaux de Marseille, faculté de médecine de Marseille, université de la Méditerranée, CHU de La Timone, 13385 Marseille cedex 05, France. patricia.niccoli-sire@ap-hm.fr

Annales D'Endocrinologie
|June 19, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MANAGEMENT OF ENDOCRINE DISEASE: Outcome of adrenal sparing surgery in heritable pheochromocytoma.

European journal of endocrinology·2015
Same author

2012 European thyroid association guidelines for genetic testing and its clinical consequences in medullary thyroid cancer.

European thyroid journal·2014
Same author

A conservative management is preferable in milder forms of pituitary tumor apoplexy.

Journal of endocrinological investigation·2010
Same author

Iodine biokinetics and radioiodine exposure after recombinant human thyrotropin-assisted remnant ablation in comparison with thyroid hormone withdrawal.

The Journal of clinical endocrinology and metabolism·2010
Same author

Could primary hyperparathyroidism-related hypercalcemia induce hypercalcitoninemia?

Hormone research in paediatrics·2010
Same author

Limited value of 18F-F-DOPA PET to localize pancreatic insulin-secreting tumors in adults with hyperinsulinemic hypoglycemia.

The Journal of clinical endocrinology and metabolism·2009
Same journal

Corrigendum to 'Pink adipose tissue: A paradigm of adipose tissue plasticity' [Ann. Endocrinol. 85 (2004) 248-51].

Annales d'endocrinologie·2026
Same journal

Intraoperative location of parathyroid glands during total thyroidectomy: a systematic review of the literature according to the PRISMA method.

Annales d'endocrinologie·2026
Same journal

Clinical and genetic diagnosis of PHP1A associated with hypogonadism in a young male: A case report.

Annales d'endocrinologie·2026
Same journal

Autoimmune features in acquired generalized lipodystrophy and anti-perilipin 1 antibodies: A case report.

Annales d'endocrinologie·2026
Same journal

The diagnostic challenge of occult glucocorticoid exposure causing Cushing's syndrome.

Annales d'endocrinologie·2026
Same journal

ACTH-dependent Cushing's syndrome in MEN1: When multiple tumors complicate the diagnosis.

Annales d'endocrinologie·2026
See all related articles

Medullary thyroid carcinoma (MTC), a cancer of thyroid C cells, is diagnosed using calcitonin (CT) levels and RET gene mutations. Early detection and complete surgery improve prognosis, with survival rates reaching 95% when CT normalizes post-operation.

Area of Science:

  • Endocrinology
  • Oncology
  • Genetics

Background:

  • Medullary thyroid carcinoma (MTC) originates from thyroid C cells and accounts for 5-10% of thyroid cancers.
  • Diagnosis often involves a solitary nodule, nodal metastasis, and elevated calcitonin (CT) levels, its biological marker.
  • MTC can be sporadic or familial (30%), linked to RET proto-oncogene mutations in multiple endocrine neoplasia syndromes.

Purpose of the Study:

  • To highlight the importance of biological (CT) and genetic (RET) markers in MTC diagnosis and management.
  • To emphasize the role of screening and early detection for optimal surgical outcomes.
  • To discuss current and future therapeutic strategies for MTC.

Main Methods:

  • Routine calcitonin (CT) measurements for screening and early diagnosis in nodular thyroid diseases.

Related Experiment Videos

  • Genetic testing for RET mutations to identify familial MTC and at-risk individuals.
  • Surgical resection (total thyroidectomy with nodal dissection) as primary treatment.

    • Main Results:

    • Elevated basal CT levels confirm MTC diagnosis.
    • RET gene analysis identifies hereditary forms, enabling prophylactic surgery in at-risk subjects.
    • Complete surgical resection is crucial for MTC treatment, with prognosis tied to disease stage and surgical extent.

    Conclusions:

    • Optimal diagnosis and treatment of MTC rely on both CT and RET markers.
    • Early detection and complete surgery significantly improve patient survival rates.
    • Future treatments may involve radioimmunotherapy and RET-targeted gene therapy for advanced or metastatic MTC.