Related Experiment Video
Updated: Jul 14, 2026

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
Published on: March 17, 2023
Pathophysiological significance of adiponectin.
Makoto Nishida1, Tohru Funahashi, Iichiro Shimomura
1Health Care Center, Osaka University 1-17 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan. makoton@imed2.med.osaka-u.ac.jp
Adiponectin, an abundant adipose-specific transcript, is inversely associated with obesity and cardiovascular risk factors. Low adiponectin levels correlate with increased incidence of cardiovascular disease and diabetes, suggesting therapeutic potential.
Area of Science:
- Endocrinology
- Metabolic Research
- Cardiovascular Science
Background:
- Adipose tissue is a source of bioactive substances, including adiponectin.
- Adiponectin is the most abundant adipose-specific transcript.
- Its serum levels are inversely associated with body weight and abdominal visceral fat.
Purpose of the Study:
- To summarize the known functions and clinical significance of adiponectin.
- To explore adiponectin's role in metabolic syndrome and related diseases.
- To highlight adiponectin as a potential therapeutic target.
Main Methods:
- Review of epidemiological and clinical studies.
- Analysis of associations between adiponectin levels and various health parameters.
- Synthesis of recent research on adiponectin's biological functions.
Main Results:
- Adiponectin levels are inversely related to cardiovascular risk factors (insulin resistance, blood pressure, LDL, triglycerides) and positively related to HDL cholesterol.
- Low adiponectin concentration is linked to higher incidence of cardiovascular disease, diabetes, and cancer.
- Adiponectin exhibits anti-inflammatory, antiatherogenic, and antidiabetic properties.
Conclusions:
- Adiponectin is clinically significant and plays a key role in metabolic syndrome.
- Adiponectin's functions may help prevent and treat obesity-related diseases and cardiovascular disease.
- Enhancing adiponectin secretion or action presents a promising therapeutic strategy.
More Related Videos
10:40Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro
Published on: December 5, 2025
09:20An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
Published on: May 4, 2021
Related Concept Videos
cAMP-dependent Protein Kinase Pathways
Insulin: The Receptor and Signaling Pathways
Cholesterol: Significance and Regulation
Considering cholesterol and...
Regulation of Food Intake
PI3K/mTOR/AKT Signaling Pathway
Adrenergic Receptors: β Subtype
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors have equal affinities for...