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Related Experiment Video

Updated: Jul 14, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
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Published on: May 10, 2022

Fetal hematocrit decrease after repeated intravascular transfusions in alloimmunized pregnancies.

Gustavo Lobato1, Cristina Silveira Soncini

  • 1Fetal Medicine Unit, Department of Obstetrics, Fernandes Figueira Institute, Oswaldo Cruz Foundation (IFF-FIOCRUZ), Rio de Janeiro (RJ), Brazil. lobato@iff.fiocruz.br

Archives of Gynecology and Obstetrics
|June 19, 2007
PubMed
Summary

Repeated intrauterine fetal transfusions (IUTs) show a decreased fetal hematocrit (Hct) drop-off after the third transfusion. This suggests longer intervals between IUTs may be possible for treating fetal hemolytic anemia.

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Last Updated: Jul 14, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
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Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System
07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Published on: May 5, 2018

Area of Science:

  • Perinatal Medicine
  • Fetal Medicine
  • Hematology

Background:

  • Intrauterine fetal transfusions (IUTs) are critical for managing fetal hemolytic anemia.
  • Assessing fetal hematocrit (Hct) changes after repeated IUTs is essential for optimizing treatment protocols.

Purpose of the Study:

  • To evaluate the decrease in fetal Hct following repeated intravascular IUTs.
  • To test the hypothesis that consecutive IUTs result in a lower Hct drop-off.

Main Methods:

  • Retrospective analysis of pregnancies undergoing IUT for fetal hemolytic anemia (July 1996-June 2006).
  • Calculation of daily fetal Hct decrease rate between transfusions.
  • Exclusion of fetuses with other abnormalities or those receiving intraperitoneal transfusions.

Main Results:

  • Eighty-one women underwent 296 IUTs, with 89.9% perinatal survival.
  • Hydropic fetuses exhibited a significantly higher Hct drop-off compared to nonhydropic fetuses (P < 0.01).
  • A lower daily fetal Hct decline was observed after the third IUT compared to the interval between the first and second (P < 0.05). Nonhydropic fetuses showed smaller decreases at the third and fourth intervals (P < 0.01 and P < 0.05, respectively).

Conclusions:

  • Fetal Hct decrease lessens after certain IUTs, potentially allowing for longer intervals between transfusions.
  • Further multicenter research is recommended to develop algorithms for timing subsequent IUTs.
  • Consideration of Doppler values and estimated Hct decline is crucial for future IUT timing strategies.