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Updated: Jul 14, 2026

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
Published on: May 5, 2023
Dengue virus regulates the expression of hemostasis-related molecules in human vein endothelial cells
Zhenyou Jiang1, Xiaolong Tang, Rui Xiao
1Department of Microbiology and Immunology, Medical College, Jinan University, Huangpu Dadao 601, Guangzhou 510632, People's Republic of China.
Objectives:
Hemorrhage is considered to be the primary sign of Dengue hemorrhagic fever and Dengue shock syndrome. In the present study we focused on the mechanism in the pro- and anti-coagulation after Dengue virus infection.
Methods:
The effects of Dengue virus on the expression and secretion of tissue factor, tissue factor inhibitor, thrombomodulin, tissue plasminogen activator and plasminogen activator inhibitor type-1 in human umbilical vein endothelial cells were detected in this study.
Results:
It was shown that Dengue virus could promote the expression of thrombomodulin in cultured human umbilical vein endothelial cells, thus increasing anticoagulation, and enhancing tissue plasminogen activator activity and therefore increased hemorrhage risk.
Conclusions:
The changes above may play an important role in the development of Dengue hemorrhagic fever and Dengue shock syndrome.
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