Related Experiment Videos
Site of action of hypertonic saline in the canine lung
1Clinical Sciences Division, Western Australian Research Institute for Child Health, Perth.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|October 1, 1991
Abstract:
The site of action of inhaled hypertonic saline was determined in 8- to 10-wk-old puppies by combining measurements of respiratory mechanics, made during mechanical ventilation and after midexpiratory flow interruptions, with direct measurements of alveolar pressure. Under both control conditions and after inhalation of 10% saline, we were able to partition lung mechanics into components representing the airways and tissue viscoelastic properties. Hypertonic saline challenge altered lung mechanics by increasing airway resistance and did not have any effect on elastic or viscoelastic properties of the lung.