Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Psychosexual Theory of Development01:14

Psychosexual Theory of Development

Sigmund Freud's psychosexual theory of development suggests that early childhood experiences significantly shape personality and behavior. Freud proposed that development is discontinuous, occurring in five distinct stages, each defined by a focus on different erogenous zones. He believed that failure to resolve the conflicts specific to each stage successfully could result in fixation, potentially influencing behavior as adults.
The Five Stages of Psychosexual Development
Freud's psychosexual...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Test of the Gravitational Force Law on Cosmological Scales Using the Kinematic Sunyaev-Zeldovich Effect.

Physical review letters·2026
Same author

Dyslipidaemia and inflammation are risks for subclinical atherosclerotic vascular disease among chronic kidney failure patients in South Africa.

PloS one·2025
Same author

The prevalence of hand pathology in regional orthopaedic hospitals in KwaZulu-Natal: A cross-sectional study.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
Same author

Response to Doctors for Life.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
Same author

Decriminalising and legalising medical assistance in dying.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024
Same author

Artificial intelligence (AI) or augmented intelligence? How big data and AI are transforming healthcare: Challenges and opportunities.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2024

Related Experiment Video

Updated: Jul 14, 2026

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
19:57

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

Paediatric HIV/AIDS disclosure: towards a developmental and process-oriented approach.

A Lesch1, L Swartz, A Kagee

  • 1Department of Psychology, University of Stellenbosch, Matieland, South Africa. alesch@sun.ac.za

AIDS Care
|June 19, 2007
PubMed
Summary

Disclosing HIV diagnosis to children is crucial as more children with HIV/AIDS live longer. A process-oriented approach, considering cognitive development, is recommended for age-appropriate HIV information delivery.

More Related Videos

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting
06:16

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Published on: June 6, 2020

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

Related Experiment Videos

Last Updated: Jul 14, 2026

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
19:57

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting
06:16

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting

Published on: June 6, 2020

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

Area of Science:

  • Pediatric Infectious Diseases
  • Child Psychology
  • Public Health

Background:

  • Antiretroviral therapy (ART) availability increases lifespan for children with HIV/AIDS.
  • Disclosure of HIV status to infected children is a growing concern.
  • Cognitive development theories inform disclosure strategies.

Purpose of the Study:

  • To review literature on HIV disclosure to children.
  • To advocate for a process-oriented disclosure approach.
  • To address challenges faced by healthcare workers and caregivers.

Main Methods:

  • Literature review on HIV disclosure in pediatric populations.
  • Analysis of disclosure challenges through the lens of cognitive development.
  • Examination of healthcare provider and caregiver perspectives.

Main Results:

  • Healthcare workers generally support disclosure, while caregivers are often more reluctant.
  • Disclosure involves complex information control and best interest considerations.
  • Contradictory views on disclosure exist between healthcare providers and caregivers.

Conclusions:

  • A process-oriented approach is needed for discussing HIV with children.
  • Practical interventions are necessary to support age-appropriate pediatric HIV disclosure.
  • Effective disclosure requires tailored information delivery based on cognitive development.