Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of lung volume and positional changes on pulmonary diffusing capacity and its components.

H Stam1, F J Kreuzer, A Versprille

  • 1Department of Pulmonary Diseases, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|October 1, 1991
PubMed
Summary

Body position significantly impacts lung diffusing capacity in healthy individuals. Supine posture generally increases diffusing capacity normalized per alveolar volume, especially in younger subjects, but this effect diminishes with age.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pros and Cons of Randomized Controlled Trials and Benchmarking Controlled Trials in Rehabilitation: An Academic Debate within the European Academy of Rehabilitation Medicine.

Journal of rehabilitation medicine·2022
Same author

Germination of conidia of Aspergillus niger is accompanied by major changes in RNA profiles.

Studies in mycology·2013
Same author

The effect of natamycin on the transcriptome of conidia of Aspergillus niger.

Studies in mycology·2013
Same author

Rate of progression and predictive factors for pulmonary outcome in children and adults with Pompe disease.

Molecular genetics and metabolism·2011
Same author

COPD and cancer mortality: the influence of statins.

Thorax·2009
Same author

Pre-operative pulmonary evaluation of lung cancer patients: a review of the literature.

The European respiratory journal·2009

Area of Science:

  • Pulmonary Physiology
  • Respiratory Medicine
  • Lung Function Testing

Background:

  • Body positioning affects lung volumes and gas exchange.
  • Diffusing capacity of the lung (DL) and its components vary with posture.

Purpose of the Study:

  • To investigate the effects of body position (sitting vs. supine) on lung diffusing capacity (DL), membrane conductance (Dm), and pulmonary capillary blood volume (Qc) in healthy volunteers.
  • To analyze how age influences these positional changes.

Main Methods:

  • Studied 37 healthy volunteers, measuring DL, DL/VA, Dm, and Qc at different lung volumes in both sitting and supine positions.
  • Analyzed DL/VA as a function of alveolar volume (VA) and assessed changes with posture and age.

Main Results:

Related Experiment Videos

  • DL/VA increased in the supine position compared to sitting, particularly in subjects under 50 years old.
  • Functional residual capacity (FRC) decreased in the supine position, influencing total DL.
  • Effective pulmonary capillary blood volume (Qc) was higher in the supine position, with the difference decreasing with age. Membrane conductance (Dm) decreased above 80% TLC in the supine position.

Conclusions:

  • Body position significantly alters lung diffusing capacity parameters, with supine posture generally enhancing DL/VA.
  • Age modulates the response of DL and Qc to postural changes.
  • Positional changes in FRC and Qc are critical factors influencing overall DL measurements.