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Updated: Jul 14, 2026
08:49
Murine Ileocolic Bowel Resection with Primary Anastomosis
Published on: October 29, 2014
Early symptomatic recurrence after intestinal resection in Crohn's disease is unpredictable
M A Kurer1, K M Stamou, T R Wilson
1Academic Department of Surgery, York Hospital, York, UK. mohamed.kurer@york.nhs.uk
Summary
Predicting early Crohn's disease recurrence after surgery is challenging. This study found no clear predictors, and smoking cessation or metronidazole did not prevent recurrence within 36 months.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Clinical Medicine
Background:
- Crohn's disease (CD) recurrence after intestinal resection is common.
- Identifying predictors of early symptomatic recurrence is crucial for patient management.
- Postoperative strategies aim to minimize disease relapse.
Purpose of the Study:
- To identify predictors of early symptomatic recurrence of Crohn's disease (CD) after surgical resection.
- To evaluate the impact of smoking and metronidazole on recurrence rates.
Main Methods:
- A cohort of 128 patients undergoing intestinal resection for CD was studied.
- Data on potential predictors including demographics, disease characteristics, and treatment were collected.
- Early recurrence was defined as symptomatic recurrence within 36 months, confirmed by objective means.
Main Results:
- Of 98 patients with at least 36 months follow-up, 48 (49%) experienced early recurrence.
- No significant predictors for early symptomatic recurrence were identified.
- Trends suggested fewer recurrences in colonic disease (P=0.068), but smoking cessation and metronidazole did not show a protective effect.
Conclusions:
- Early symptomatic postoperative recurrence of Crohn's disease remains largely unpredictable.
- Contrary to expectations, smoking abstinence and adjuvant metronidazole did not prevent early recurrence in this cohort.
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