Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
Varicose Veins I: Introduction01:26

Varicose Veins I: Introduction

Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel method for trend change detection and hypothesis generation in hemovigilance: A transfusion-related immunomodulation and blood production changes study.

Transfusion·2026
Same author

Efficacy and safety of dupilumab in Hailey-Hailey disease: A multicentre cohort study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

Barriers to seeking mental health services among young persons with mental disorders in South India: a qualitative study.

East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan·2025
Same author

Epidermolytic ichthyosis: New insights and ongoing challenges.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

Disentangling Centrality Bias and Final-State Effects in the Production of High-p_{T} Neutral Pions Using Direct Photon in d+Au Collisions at sqrt[s_{NN}]=200  GeV.

Physical review letters·2025
Same author

French national protocol for the management of congenital ichthyosis.

Annales de dermatologie et de venereologie·2024

Related Experiment Video

Updated: Jul 14, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Extensive venous/lymphatic malformations causing life-threatening haematological complications.

J Mazereeuw-Hautier1, S Syed, R I Leisner

  • 1Department of Dermatology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1 3JH, UK. mazereeuw-hautier.j@chu-toulouse.fr

The British Journal of Dermatology
|June 19, 2007
PubMed
Summary

Patients with large slow-flow malformations (SFM) risk serious bleeding and clotting. Regular coagulation screening and early anticoagulation are vital for managing these rare but life-threatening complications.

More Related Videos

A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

Related Experiment Videos

Last Updated: Jul 14, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

Area of Science:

  • Vascular Malformations
  • Hematology
  • Pediatric Dermatology

Background:

  • Large slow-flow malformations (SFM) can lead to coagulopathy, thrombosis, and hemorrhage.
  • These severe complications of SFM are rarely reported.

Observation:

  • A cohort of six children (ages 1-20) with massive SFM experienced pain, necrosis, bleeding, and intravascular coagulopathy.
  • Life-threatening events included brain hemorrhage, massive organ bleeding, deep vessel thrombosis, and hemoptysis.
  • One patient died from pulmonary thromboembolism; another had a leg amputation due to the malformation's risks.

Findings:

  • All patients presented with intravascular coagulopathy and severe, life-threatening complications.
  • Anticoagulation treatment in three patients led to improved coagulopathy.
  • The study highlights the severe risks associated with extensive SFM.

Implications:

  • Regular coagulation screening is essential for patients with extensive SFM to detect intravascular coagulopathy.
  • Early anticoagulation is crucial to prevent secondary complications like thrombosis and hemorrhage.
  • This research underscores the need for vigilant management of hematological complications in SFM patients.