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Related Experiment Videos

Planar polarity and tissue morphogenesis.

Jennifer A Zallen1

  • 1Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10021, USA. zallenj@mskcc.org

Cell
|June 19, 2007
PubMed
Summary
This summary is machine-generated.

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Planar cell polarity (PCP) systems coordinate cell behavior using cell-to-cell communication. This review explores how directional signals transmit between cells in both stationary and dynamic populations.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Systems Biology

Background:

  • Planar polarity is a global, tissue-level coordination of cell behavior in a 2D plane.
  • The Frizzled/planar cell polarity (PCP) and anterior-posterior (AP) patterning systems are key regulators of cell directionality.
  • These systems operate across diverse cell types with varying morphologies and behaviors.

Purpose of the Study:

  • To review the current understanding of planar polarity mechanisms.
  • To elucidate how directional signals are transmitted between neighboring cells.
  • To compare strategies for generating global spatial information in different cell populations.

Main Methods:

  • Literature review of studies on planar cell polarity.
  • Analysis of molecular mechanisms underlying signal transmission.

Related Experiment Videos

  • Comparative analysis of stationary and dynamic cell population strategies.

    • Main Results:

    • PCP and AP systems utilize distinct protein sets but rely on local cell-to-cell communication for directional cues.
    • Mechanisms of directional signal transmission are conserved across different biological contexts.
    • Strategies for establishing global spatial information differ between static and dynamic cell populations.

    Conclusions:

    • Understanding cell-to-cell communication is crucial for deciphering planar polarity.
    • Comparative approaches reveal conserved and divergent strategies in spatial information processing.
    • This review synthesizes current knowledge and highlights areas for future research in planar polarity.