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Related Experiment Video

Updated: Jul 14, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

[Contact dermatitis caused by acetazolamide under occlusion].

Amélie Daveluy1, Thierry Vial, Laurine Marty

  • 1Centre de pharmacovigilance, Département de pharmacologie, Inserm U657, Université Victor Segalen, CHU, Bordeaux. amelie.daveluy@u-bordeaux2.fr

Presse Medicale (Paris, France : 1983)
|June 19, 2007
PubMed
Summary

Topical acetazolamide can cause allergic contact dermatitis, particularly when used under occlusion after procedures like liposuction. Prompt discontinuation and treatment resolve the reaction, confirmed by positive skin tests.

Related Experiment Videos

Last Updated: Jul 14, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Area of Science:

  • Dermatology
  • Pharmacology
  • Allergology

Background:

  • Acetazolamide, a carbonic anhydrase inhibitor, is utilized topically for managing post-traumatic or post-operative edema.
  • Topical acetazolamide's potential for local allergic reactions is noted in its monograph.

Observation:

  • Two cases of extensive contact dermatitis are reported following the topical application of acetazolamide.
  • The dermatitis occurred after acetazolamide was used under compression panty post-liposuction.

Findings:

  • Discontinuation of acetazolamide led to the resolution of the cutaneous eruption.
  • Positive cutaneous tests confirmed acetazolamide as the causative agent.
  • French adverse drug reaction data revealed 10 additional cases of eczema or rash at the application site.

Implications:

  • This study highlights the risk of allergic contact dermatitis from topical acetazolamide.
  • Contraindicated occlusive application may exacerbate lesions.
  • Similar reactions have been observed with other carbonic anhydrase inhibitors like dorzolamide.