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Updated: Jul 14, 2026

An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices
Published on: August 21, 2020
Hemocompatibility of a hydrodynamic levitation centrifugal blood pump
Takashi Yamane1, Osamu Maruyama, Masahiro Nishida
1Institute of Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, 1-2 Namiki, Tsukuba, 305-8564, Japan. yamane.t@aist.go.jp
Abstract:
A noncontact type centrifugal pump without any complicated control or sensing modules has been developed as a long-term implantable artificial heart. Centrifugal pumps with impellers levitated by original hydrodynamic bearings were designed and have been modified through numerical analyses and in vitro tests. The hemolysis level was reduced by changing the pressure distribution around the impeller and subsequently expanding the bearing gap. Thrombus formation in the bearing was examined with in vitro thrombogenesis tests and was reduced by changing the groove shapes to increase the bearing-gap flow to 3% of the external flow. Unnecessary vortices around the vanes were also eliminated by changing the number of vanes from four to six.
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