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Whole-body optical imaging in animal models to assess cancer development and progression

Eric L Kaijzel1, Gabri van der Pluijm, Clemens W G M Löwik

  • 1Departments of Endocrinology and Metabolic Diseases and Urology, Leiden University Medical Center, Leiden, the Netherlands.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|June 19, 2007
PubMed

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...