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Ventricular long-axis function is of major importance for long-term survival in patients with heart failure

B Grüner Sveälv1, E L Olofsson, B Andersson

  • 1Department of Molecular and Clinical Medicine/Cardiology, Wallenberg Laboratory, Sahlgrenska Academy at Göteborg University, Sweden.

Heart (British Cardiac Society)
|June 19, 2007
PubMed

Insights

Left ventricular long-axis systolic amplitude is a crucial predictor of long-term survival in heart failure patients, independent of other clinical factors. This finding highlights the importance of basal ventricular function for patient outcomes.

Area of Science:

  • Cardiology
  • Echocardiography
  • Heart Failure Research

Background:

  • Heart failure significantly impacts long-term survival.
  • Assessing ventricular function is key to predicting outcomes.
  • Traditional assessments often focus on short-axis function.

Purpose of the Study:

  • To evaluate the predictive value of left ventricular (LV) long-axis (LAX) systolic and diastolic function compared to short-axis (SAX) function for long-term survival in heart failure patients.
  • To determine if LAX function is an independent predictor of survival.

Main Methods:

  • Prospective epidemiological study involving 228 heart failure patients (mean age <65 years, ejection fraction 44%).
  • Echocardiography was used to assess both SAX and LAX function of the right and left ventricles.
  • Patients were followed for 10 years for survival or heart transplantation.

Main Results:

  • LV LAX systolic amplitude strongly predicted long-term survival (p<0.001).
  • In multivariate analysis, LV LAX systolic amplitude was the sole independent predictor of outcome (HR 0.89, p=0.02), even after adjusting for clinical variables and SAX function.
  • Survival curves stratified by LAX systolic amplitude quartiles showed clear differentiation in outcomes.

Conclusions:

  • LV LAX systolic amplitude independently predicts survival in heart failure patients.
  • These findings underscore the significance of basal ventricular segments for overall ventricular function and long-term prognosis.
  • LAX function provides crucial prognostic information beyond SAX measures.
Abstract

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